Contemporary drugs are usually prepared in a multistep organic syntheses. Already, at the early development stage, there is a high demand for quick separation, identification and confirmation of the structure of reaction products. The GC/MS is a perfect analytical tool to meet these requirements.

Alkylation of 2,6-diamino-4,5,6,7- tetrahydrobenzothiazole with n-propyl tosylate was investigated. Besides of peaks corresponding to the starting material and the desired product (6-n-propylamino derivative), other mono-, di- and tri-n-propyl substituted 2,6-diamino-4,5,6,7- tetrahydrobenzothiazole derivatives were also observed.

In a separate experiment, acylation products of 2,6-diamino-4,5,6,7- tetrahydrobenzothiazole were investigated.

Conclusions from these experiments were usefull for the development of the process in a laboratory scale.

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