New polymeric carrier, able to bind different biologically active ligands, epoxy-containing poly-N-vinylpyrrolidone was synthesized.
The polymer was prepared in conditions of Darzan reaction. It was shown that by this method it is able to obtain with high yield water-soluble polymers which contain up to 20 molar % of epoxycontaining rings. Prepared polymer did not dissolve in the reaction spirit medium due to the presence of amide groups and precipitated.
The effect of reaction conditions - temperature, reaction time, concentration, reagents ratio and molecular weight of initial poly-N-vinylpyrrolidone on yield and containing of epoxy-groups was studied.
This method pays attention as beforehand prepared for medical purpose polymer with known molecular-weight distribution, suitable for creation of preparations, assigned for introduction into the organism. Process was controlled with determination of polymers yield and abundance of epoxy groups. Polymers structure was also confirmed by infrared spectral method.
It was determined that these polymers are able to interact with amino acids. Analysis with AMR method showed that addition of amino group passes on the atom of carbon that is a part nitrogen-containing cycle.
It was shown that synthesized polymers and their complexes with transitional metals have different types of biological activity determined by experiments with several tissue cultures.
Interconnection between metal and ligand was studied by photometry, chelatometry, potentiometry, viscometry. For determination of donor atoms, interacted with metal ions, the analysis of obtained polymers with IR and PMR spectrography methods was carried out. The estimates were made about the structure of synthesized polymeric complexes of different metals and ligand groups, placed in side chains.

References
Shtilman M.I., Tashmuhamedov R.I. et al. // 27th Intern. Symp. on Contr. Release of Bioact. Mater. [Paris,2000].- CRS.- 2000.- P.7009.

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