Traumatic brain injury (TBI) concussion is often a result of traffic accidents, contact sports as well as battlefield or terrorist explosions. TBI is classified based on severity. A mild form of traumatic brain injury (mTBI), often results in the post-concussion syndrome (PCS). Unfortunately, PCS is usually underestimated, because the immediate physical symptoms decrease rapidly and conventional neuroimaging studies of the brains of most mTBI victims often do not express any radiologicalevidence of brain lesions. However, cognitive impairments persist for weeks, months or even years after the incident. A mouse weight drop model mirrors well the mTBI-induced long-lasting learning and memory impairments observed in humans [1]. Recent results indicate that opioids, especially biphalin show promising anti-neurodegenerative properties [2]. Therefore, we decided to assess if an immediate post-injury injection of biphalin provided any benefits in mTBI behavioral impairments. After a systemic administration of biphalin we observed an improvement in spatial and recognition memory in the Morris Water Maze and Novel Object Recognition tests 7 and 30 days post-trauma. Our new data suggest that opioid receptor activation may provide neuroprotection of post-traumatic neurodegeneration processes. Further investigations will be carried out in the development of optimal post-accidental therapeutic time-window for efficacious treatment of mTBI.

Acknowledgements:

This work was supported by the Polish National Science Center (NCN), grant no. 2011/03/N/NZ4/02021 for Anna Lesniak. The technical support by Zdzislawa Kowalska is highly acknowledged.

[1] Zohar O, Rubovitch V, Milman A, Schreiber S, Pick CG 2011 Behavioral consequences of minimal traumatic brain injury in mice, Acta Neurobiol Exp 71: 36-45

[2] Kawalec M, Kowalczyk JE, Beresewicz M, Lipkowski AW, Zablocka B 2011. Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture. Neurochem Res 36: 2091-2095.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/31158 must be provided.

1. Sex differences in the opioid component of swim stress-induced analgesia in mouse lines selected for high or low sensitivity to stress
2. Comparable antinociceptive effect of biphalin in mice selected for high and low swim stress-induced analgesia after blood-brain barrier disruption caused by hyperosmolar mannitol administration
3. Assessment of analgesic potency of biphalin in a mouse model of cancer pain  
4. CONJUGATED LINOLEIC ACIDS PREPARATIONS AS EFFECTIVE NUTRACEUTICS
5. OPIOID PEPTIDE ANALOGUE AA2016 IN MOUSE MODEL OF INDIVIDUAL PAIN SENSITIVITY