Recently there is a growing interest in development of  novel nano/microstructural drug delivery systems.  They are expected to ensure safe and efficient  transport of biologically active substance to the defined tissue, where it can be released  at the required rate. Ideally, such systems should allow the targeted drug delivery and it controlled release.   Various systems of that kind have been proposed.  They include: liposomes, nano/microspheres, nano/microcapsules, nanostructural films or micellar systems.  These carriers are usually prepared from lipids and polymeric or hybride materials.  Their structure and chemical composition can be adjusted to the type of the drug and to its  therapeutic   profile.

Recent advances in that research area with the emphasis on the contribution of the author’s research group to that  field, will be described.   The following systems will be presented:

A)   Polymer supported liposomal nanosystems increasing bioavaiability of highly hydrophobic molecules  - curcumin as a model drug

B)   Microparticulate hydrogel systems  obtained based on natural polymer  and conjugates allowing the  controlled, long term  release of  unfractionated heparin

C)   Polymeric nano/microparticles ensuring  protection and delivery of protein - alkaline phosphatase as a model protein

D)   Polymeric micelles and nanospheres formed by self assembly of macromolecules  as  drug carriers

E)    Multifunctional nano/microparticles for targeted delivery

F)    Polymeric gene delivery systems

References:

[1]  M. K. Kepczynski, K. Nawalany, B. Jachimska, M. Romek,  M. Nowakowska,  Colloids and Surfaces B: Biointerfaces 49 (2006) 22–30

[2]   A. Karewicz, D. Bielska, A. Loboda, B. Gzyl-Malcher, J. Bednar, A. Jozkowicz, J. Dulak, M. Nowakowska,  Colloids and Surfaces B: Biointerfaces 109 (2013) 307– 316

[3] A. Karewicz, K. Zasada, K. Szczubiałka,  S. Zapotoczny, R. Lach. M. Nowakowska,  International Journal of Pharmaceutics 385 (2010) 163–169

[4]  K. Kaminski, K. Szczubiałka, K. Zazakowny, R. Lach, M. Nowakowska, J. Med. Chem.,2010, 53, 4141–4147

[5]  A. Karewicz,  K. Zasada, T.E.L. Douglas, J. A. Jansen, S. C. G. Leeuwenburgh, M. Nowakowska, Journal of Microencapsulation, 2014, 31(1), 68-76

[6] M. Wytrwał, P. Koczurkiewicz, K. Wójcik, M. Michalik, B. Kozik, M.        Zylewski,  M. Kępczyński, M. Nowakowska J. Biomed. Mater. Res.  Part A, 2014, 102A, 721-731

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