Hydroxyapatite (HAP), Ca₁₀(PO₄)₆(OH)₂, has the ability to chemically interact with bone both in vitro and in vivo. For this reason it has been extensively studied as a possible bone substitute material. It also finds applications such as matrices for control drug release, bone cement, toothpaste additives and dental implant. In the present study, pure zinc doped hydroxyapatite (Zn-HAP) nano- particles were synthesized and antibacterial activity was studied for their medical applications. Pure HAP and Zn-HAP nano-particles were synthesized by surfactant mediated approach. For the synthesis of pure HAP, aqueous solutions of calcium nitrate tetra-hydrate, nitric acid, potassium di-hydrogen phosphate and surfactant triton X – 100 were treated by ammonium hydroxide at appropriate temperature and pH. For the synthesis of Zn-HAP samples, different weight percentage of Zn(NO₃)₂.6H₂O was added to the Ca(NO₃)₂.4H₂O solution and the same procedure was followed as that for pure HAP nano-particles. The doping of zinc was estimated by EDAX. The average particle size was estimated by applying Scherrer’s formula to the powder XRD patterns, which was found to be 16 nm to 33 nm. Doping of zinc with different percent changed the unit-cell parameters of HAP. The TEM images of pure and Zn-HAP nano-particles were also recorded. The pure HAP had needle type morphology and agglomeration increased with the increase of dopant concentration. The FT-IR spectra suggested the presence of O-H, O-P and C-O functional group. The antimicrobial activity was evaluated against four organisms Pseudomonas aeruginosa and Shigella flexneri as Gram negative as well as Micrococcus luteus and Staphylococcous aureus as Gram positive. The nano HAP and Zn-HAP possess the good antibacterial property. The ability of new apatite formation on the surface of pure and doped HAP samples was studied using Simulated Body Fluid (SBF) in vitro. Hemolytic study indicated that all samples were non-hemolytic defining potential application as bone implant material.

1. POSTER: Pure and zinc doped nano-hydroxyapatite : synthesis, characterization, antimicrobial and hemolytic studies, Microsoft Office Document, 0MB

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