Solvothermal synthesis of nonstoichiometric hydroxyapatite nanoparticles

Witold Łojkowski 1Dariusz Smoleń 1Wojciech Swieszkowski 2Tadeusz Chudoba 1Aleksandra Kędzierska 1Jacek Wojnarowicz 1

1. Polish Academy of Sciences, Institute of High Pressure Physics (UNIPRESS), Sokolowska 29/37, Warszawa 01-142, Poland
2. Warsaw University of Technology, Faculty of Materials Science and Engineering (InMat), Wołoska 141, Warszawa 02-507, Poland


Today, the most common approach for regrow of bone in case of large bone gaps is to use autografts. In this case two or more operations are needed, with increased risk, suffering and costs for the patient. There is also an emerging market for hydroxyapatite (HAp) and calcium phosphate (TCP) in the form of paste or granulates used to fill small bone gaps. For large bone gaps bone regrowth scaffolds are being developed, but still exist unsolved problems like: low regrowth rate, poor mechanical properties of the scaffolds, high risk of inflammatory processes and slow or no resorbtion. Therefore the main objectives of the current regeneration medicine projects is to develop the technology for a bioactive scaffold with improved comparing to  the state of the art control of shape, mechanical properties, bioactivity and resorbability. One of the ways to achieve these goals is to produce nonstoichiometric nanoparticles of hydroxyapatite with grain size lower than 10 nm and shape close to the natural HAp which will be used as material for bioactive, mechanically strong scaffolds.

The Institute of High Pressure Physics of the Polish Academy of Sciences (IHPP) is an expert in synthesis of doped nanoparticles with narrow size distribution, at relatively low temperatures by using Microwave Solvothermal Synthesis (MSS) technology. The MSS technology permits synthesis of nanoparticles with precise control of the reaction time, temperature and pressure. IHPP and the Faculty of Materials Science, Warsaw University of Technology, created a joint Center for Bionanomaterials and started cooperation to develop materials for bone regrowth scaffolds. Thanks to unique worldwide reactors for microwave solvothermal synthesis of nanoparticles, IHPP is able to synthesize unique HAp nanoparticles using the standard reaction: 

Ca(OH)2 + H3PO4 → HAp + H2

The reaction is carried out in water solution in time lower than 5 minutes. The specific surface is almost 240m2/g, the average grain size lower than 10 nm with shape in the form of platelets mimicking the natural bone particles.


Legal notice
  • Legal notice:

    Copyright (c) Pielaszek Research, all rights reserved.
    The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
    In every case, proper references including Author(s) name(s) and URL of this webpage: must be provided.


Related papers
  1. Optical oxygen sensor for safe operation in hazardous areas
  2.   Optical oxygen sensor for safe operation  in hazardous areas
  3. Quo Vadis nanotechnology- for various stakeholders
  4. Opening of the Thursday Sessions of NanoPl 2014
  5. Microwave reactors for nanoparticle's synthesis
  6. Opening of Nano-Bio-Med session
  7. Bioactive GoHAP nanoparticles and their applications in medical implants technology
  8. Wykorzystanie metody NTA (Nanoparticle Tracking Analysis) w ocenie wielkości krążących mikrocząstek osocza i innych płynów fizjologicznych: pułapki i triki
  9. Advanced characterisation of nanomaterials according to ISO 17025 Norm

  10. Microwave solvothermal synthesis of resorbable nano-HAp with controlled grain size.
  11. Electrospun nanocomposites from PHBV for bone tissue engineering
  12. Microwave Solvothermal Synthesis of High Quality Nanoparticles
  13. Microwave Solvothermal Synthesis of Nano Zinc Oxide Nanoparticles
  14. Microwave Solvothermal Technology (MSS) for nanoparticle synthesis
  15. Zaawansowana Charakteryzacja Nanocząstek
  16. [CEPT] Solvothermal synthesis nano zinc oxide in  microwave reactor MSS2
  17. [CEPT] Solvothermal synthesis and characterization of nanomaterials in the Laboratory of Nanostructures for Photonics and Nanomedicine, Center of Bio-Nanomaterials
  18. Scanning Electron Microscopy Investigations and Analysis of Nanostructures
  19. Polish Nanotechnology Platform - a discussion group at Linked-In
  20. Novel optical oxygen sensor for life and health protection made of nano-zirconia
  21. Nanometrology as a tool for nanotechnology problems solving
  22. Creating a Polish Nano-Bio-Technology and  Nano-Medicine Platform?
  23. MSS synthesis of highly biocompatible nano-HAP and coating of 3D poymer scaffolds
  24. Nanotechnologie w gospodarce województwa podlaskiego
  25. Characterization of nanomaterials according to EU recommendations, on the example of ZnO nanoparticles
  26. [CEPT] Nanohydroxyapatite-polylactide composites  for regenerative implants
  27. [CEPT] MSS synthesis of highly biocompatible nano-HAP with properties depending on the synthesis time.
  28. [CEPT] Studies of nanoparticles size distribution
  29. [CEPT] Studies of solubility of nanoparticles and stability of their suspension
  30. Iinvestigation of nanoparticles by DSC-TG methods accompanied by chemical analysis of emitted gas
  31. Green Technology and Pilot Unit for Manufacturing of Ultra Clean Concentrated Colloids of Nano Metals
  32. NanoVelos - biotechnological start-up founded by GIZA Polish Ventures. How VC fund may turn your idea into the company with a global perspective
  33. Presentation of the  Laboratory of Nanostructures for Photonics and Nanomedicine, Center of Bio-Nanomaterials, CePT
  34. ZnO nanoparticles effect on integrity of human endothelial cells
  35. Importance and trends in nanomedicine according  European Nanomedicine Platform survey
  36. Application of the Zeiss Ultra Plus scanning microscopy in bio-nanotechnology 
  37. Application of micro- and nanostructured biomaterials in regenerative medicine
  38. Welcome address
  39. Core-shell P(LLA-CL) based electrospun nanofibers for peripheral nerve tissue engineering
  40. Otwarcie NanoInfoDay, Powitanie
  41. Characteristic of hydroxyapatite dense nanoceramic produced by The High Pressure Consolidation  
  42. Wpływ parametrów materiałowo-technicznych na właściwości optycznego czujnika tlenu na bazie nano-ZrO2
  43. Synteza nano-ZnO przy pomocy reaktora Mettler Toledo w Laboratorium Nanostruktur dla Fotoniki i Nanomedycyny CePT.
  44. Infrastruktura i specjalizacje nanotechnologii w Polsce na podstawie wyników ankiety NANOFORCE
  45. Solwotermalna synteza domieszkowanego nanotlenku cynku dla projektu NanoFATE. Otrzymywanie wodnych nanozawiesin domieszkowanego tlenku cynku.
  46. Nanotechnologia bezpieczna dla ludzi i przyjazna środowisku
  47. Badania rozkładu wielkości cząstek i potencjału zeta w Laboratorium Nanostruktur dla Fotoniki i Nanomedycyny CePT
  48. Badanie stabilności i rozpuszczalności zawiesin z nano ZnO i nano ZnO:Co otrzymanych w  Laboratorium Nanostrutur dla Fotoniki i Nanomedycyny CePT
  49. Badania nanoproszków przy pomocy technik DSC-TG/ QMS-FTIR w Laboratorium Nanostruktur dla Fotoniki i Nanomedycyny CePT
  50. Synthesis of highly biocompatible hydroxyapatite nanopowders
  51. Nanosafety - challenge of nowadays
  52. Influence of heat treatment on luminescence of ZrO+ Eu nanopowders
  53. Solvothermal synthesis of doped nano zinc oxide for the project NanoFATE.
  54. Podsumowanie
  55. Solwotermalna synteza domieszkowanego nano tlenku cynku dla projektu NanoFATE.
  56. Hydrothermal Synthesis of Zinc Oxide Nanopowders
  57. Optyczny sensor tlenu na bazie nanokrystalicznego ZrO2
  58. Solvothermal synthesis of nonstoichiometric hydroxyapatite nanoparticles
  59. Procedury charakteryzacji nanoproszków
  60. Oferty nanoproszków - Laboratorium Nanostruktur, Instytut Wysokich Ciśnien PAN
  61. Nanofotonika dla małych i średnich przedsiębiorstw - mapy dorogowe i analizy SWOT  najważniejszych technologii.
  62. Otwarcie konferencji
  63. Polska  Platforma Nanotechnologii i zarys strategicznego programu "Nanotechnologia i wzrost inwestycji w B&R w Polsce"
  64. Nowe mikrofalowe reaktory do syntez nanocząstek - wybrane zagadnienia badawcze i przykłady zastosowań
  65. Micro Sensor for cell force measurement
  66. ZrO2:Tb nanopowders obtained by coprecipitation method
  67. Investigation of the DLC and novel DLC-polymer hybrid coatings using FIB and SEM techniques
  68. A combination of microCT and FEM methods for development of a new scaffold for bone regeneration
  69. ZnFe2O4/ZnO core-shell particles obtained by coprecipitation route
  70. Synthesis of gallium nitride nanowires by Sublimation Sandwich Method
  71. Synthesis of aluminum nitride nanopowder; compare methods for determination of the grain size in nanopowders 
  72. Hydrothermal Synthesis of ZnAl2O4 Spinel
  73. Electrospun polymeric fibers for cartilage regeneration
  74. Biodegradable and bioabsorbable polymeric - ceramic composites for medical applications
  75. Preliminary examinations of mechanical properties of DLC and novel DLC-polymer hybrid coatings for resurfacing hip prostheses
  76. Optimization of the polymeric scaffolds for bone tissue engineering fabricated by rapid prototyping method
  77. Localization of rare-earth dopants in the lattice of nanocrystalline ZrO2 - EXAFS study
  78. Advanced nanoporous yttria-stabilized zirconia ceramics for luminescent oxygen sensors
  79. Novel method for bone tissue scaffold fabrication. Influence of composition chitosan/beta-TCP matrixes on mechanical and biological properties.
  80. Excitation transfer in zirconia nanocrystals and ceramics
  81. Eu Luminescence in zirconia nanocrystals
  82. ZnO ceramic sintering and luminescence properties
  83. Oferta zaawansowanych materiałów w perspektywie 5 - 20 lat
  84. Strategia rozwoju badań nanoproszków
  85. Error bars in powder diffraction
  86. Synthesis of doped ZnO nanopowders in microwave hydrothermal reactors
  87. Characterization of nanopowders
  88. Synthesis of Al doped ZnO nanopowders and their enhanced luminescence
  89. Synthesis of nanopowders in supercritical water in a continuous flow reactor
  90. A summary of results obtained in Working Group 002 "Synthesis and Processing of Nanopowders"
  91. Summary of activities of Working Group D30/003 "Synthesis and Processing of Nanopowders"
  92. Doped zirconia nanopowders made in microwave – pressure reactor
  93. Combining microwave and pressure techniques for hydrothermal synthesis of ZnO and ZrO2 nanopowders doped with a range of metal ions
  94. Luminescence properties of zinc oxide nanopowders doped with Al ions obtained by the hydrothermal and vapour condensation methods.
  95. Mechanical property of nano-TiO2 dispersed Al65Cu20Ti15 amorphous/nanocrystalline matrix bulk composite prepared by mechanical alloying and high pressure sintering
  96. Microwave technique applied on the hydrothermal synthesis and sintering of calcia stabilized zirconia nanoparticles
  97. Luminescence properties of cerium doped Y3Al5O12 nanopowders and nanoceramic
  98. Yttrium-Aluminum Garnet Synthesized in the Medium of Supercritical Fluids
  99. Advanced nanostructural zirconia ceramics for optical oxygen sensors
  100. Study of undoped and doped zirconia nanocrystals luminescence
  101. Doping of ZnO nanopowders with Mn, Ni and Cr In an ultrasound and microwave driver hydrothermal reaction
  102. Localization of rare-earth dopants in the lattice of nanocrystalline ZrO2 - EXAFS study
  103. Zirconia-based nanomaterials for oxygen sensor - generation, characterisation and optical properties
  104. Repair and regeneration of osteochondral defects in the articular joints
  105. Production of doped and non doped ceramics nanoparticles for optical applications
  106. Synthesis, sintering and properties of doped nanocrystalline powders of zirconia, zinc oxide and yttrium aluminum garnet (YAG)
  107. Characterization of nanocrystalline ZrO2 doped with Rare-Earth elements synthesized via High Pressure Hydrothermal Method
  108. Particle Size Distribution of ZrO2:Pr3+- Influences of pH, High Power Ultrasound, Surfactant and Dopant Quantity
  109. Time-Resolved Luminescence Characteristics of Doped YAG and YAP Nanopowders
  110. Cathodoluminescence of Al doped ZnO nanopowders
  111. Morphology of Al doped Zinc Oxide Obtained using Hydrothermal and Vapour Condensation Methods
  112. Luminescence and structural properties of rare-earth doped YAG nanoceramics
  113. Optimization of conditions of preparation of YAG nanopowders for sintering of translucent ceramics
  114. The influence of ZrO2 containing 10% Eu 3+ on the polyurethane hard domain structure of nano-composites with luminescence properties
  115. Growth and properties of ytterbium doped KY(WO4)2 nanocomposites
  116. Investigations on the utilization of nano zinc oxides synthesized by hydrothermal method in rubber compounds
  117. Doping of ZnO nanopowders with Mn and Cr in an ultrasound and microwave driven hydrothermal reaction
  118. Investigations of phase composition and grain size distribution in Pr doped ZrO2
  119. Nasze wyniki, zdania i sposoby ich realizacji
  120. Morphology of Al doped zinc oxide obtained by the vapour condensation method
  121. The comparison of the properties of YAG obtained by coprecipitation and SCR method
  122. Synthesis of nanopowders at elevated pressure and their characterisation - summary of work of the WG-002
  123. Accuracy of XRD size measurements of nanocrystals
  124. Morphology of Al-Doped Zinc Oxide Obtained by the Vapour Condensation Methods
  125. SWOT analysis of various reactors used for synthesis of nanopwoders in our Working Group
  126. Preliminary research on zirconia based optical oxygen sensor
  127. Preparation and electrical properties of the BaTiO3 nanoceramics
  128. Current trends in the development of metallic nanomaterials: results of a study carried out within the EC project Nanoroad SME
  129. Microstructural Evolution in Mechanical Alloying and Hot Pressing of Aluminium and 316 Stainless Steel Powder Blend
  130. Time-resolved luminescence of nanostructured ZnO
  131. Prediction of degree of localisation of misfit dislocation cores in intercrystalline interfaces based on interfacial adhesion
  132. Kinetic and thermodynamic factors leading to dissolution of cementite in pearlitic steel subjected to severe plastic deformation under pressure
  133. Yttria stabilized zirconia nanocrystals luminescence
  134. Application of XRD diffraction methods for determination of grain size distribution in nanoparticles
  135. Optical investigations of RE-doped YAG nanoceramics
  136. Electrical properties of nanocrystalline ZrO2 at high-pressure
  137. High-pressure Induced Structural Decomposition of RE-doped YAG Nanoceramics
  138. Synthesis of Al-doped ZnO nanomaterials with controlled luminescence properties
  139. Combination of ECAP and Hydrostatic Extrusion for ultra-fine grain (UFG) microstructure generation in 99.98% nickel.
  140. Mechanical properties and deformation behaviour of ultra-fine grained nickel.
  141. Grain Size and Grain Size Distribution of Nanocrystalline Pr-doped Zirconia Powders Obtained in High Pressure Microwave Reactor
  142. Influence of synthesis conditions on the particles size and the morphology of zinc oxide nanopowders
  143. Measuring the Grain Size Distribution of Pr-doped Zirconia Nanopowders obtained by Microwave Driven Hydrothermal Synthesis
  144. Excellent mechanical properties of UFG metals and alloys, subjected to combination of severe plastic deformation methods.
  145. An FT-IR Spectroscopic Investigation of Hydroxide Groups in Nano-Crystals of ZrO2.
  146. Development of microstructure and mechanical properties in nickel deformed by hydrostatic extrusion
  147. Structural and luminescence properties of yttrium-aluminum garnet (YAG) nanoceramics
  148. Biocompatibility of thin films based on hydrothermal synthesized HAp
  149. Hybrid HAp- maleic anhydride copolymer nanocomposites obtained by in situ functionalisation
  150. Fabrication and electrical properties of Eu3+:BaTiO3 nanoceramics for SOFC
  151. Luminescence of ZrO2 nanocrystals
  152. Molecular impurities in the luminescent ZnO nanocrystals
  153. X-Ray investigations of the natural and artificial White Etching Layer
  154. Diffusion and diffusion induced defects in GaN
  155. Excellent Mechanical Properties of Nickel Processed by High Pressure Techniques
  156. Microwave driven hydrothermal synthesis of iron oxide - the effect of process parameter on the properties of the nanopowders
  157. Relaxation processes in ZrO2 at high pressures
  158. Luminescence of ZrO2 and ZnO nanocrystals
  159. Zinc oxide nanopowders obtained by the microwave-hydrothermal route
  160. Microwave driven hydrothermal synthesis of Pr-doped zirconia nanopowders
  161. New hydroxyapatite based nanomaterials for potential use in medical fields
  162. Correlation between high-pressure ZrO2 electrical properties and crystallite size
  163. Precise determination of full Grain Size Distribution from diffraction peak profile as a result of kinematical theory of diffraction for polidispersive nanomaterials
  164. Pressure Effect on Grain Boundary Diffusion in Al Bicrystals
  165. Microstructure of Surface Layers of Raiways After Heavy Exploatation
  166. Application of High Pressure to Processing of Meat
  167. Normal Grain Growth in 2-d Strips of Polycrystalline Aluminium Under High Pressure
  168. Reaction Diffusion in Metallic Systems under High Pressure
  169. High Pressure Effect on Grain Boundary Wetting in Aluminium Bicrystals
  170. Pressure Effect on Interface Energy, Diffusion and Reactions
  171. Transformation of fractal microstructure of nanocrystalline SiC and diamond in high pressures - Small Angle Scattering Study
  172. Microwave-Hydrothermal Synthesis of Nanostructured Pr-Doped Zirconia Powders
  173. The Strain Induced Cementite Dissolution in Carbon Steels-Experimental Facts and Theoretical Approach
  174. Effect of SPD Grain Refinement and Peculiarity of Structure and Mechanical Properties of UFG Ni
  175. Luminescense of Nanosize ZrO2
  176. Structure, Morphology and Luminescence Properties of Pr-doped Nanocrystalline ZrO2 Obtained by Hydrothermal Method
  177. Nanostructure Formation on the Surface of Railway Tracks and Wheelsets
  178. Hydrothermal Synthesis of Zinc Oxide Nanopowders with Microwaves Applications
  179. Microwave Driven Hydrothermal Synthesis of Iron Oxide Nanopowders
  180. Indentation Technique for Determination if Mechanical Behavior of Nanomaterials (Bulk and Coatings)

Presentation: Poster at Warsaw and Karlsruhe Nanotechnology Day, by Dariusz Smoleń
See On-line Journal of Warsaw and Karlsruhe Nanotechnology Day

Submitted: 2011-08-29 10:03
Revised:   2011-08-29 10:03