Our research group is focusing on developing of new olefin metathesis catalysts [3]. Some of our catalysts have found successful applications in the synthesis of a number natural and biologically active products [3]. In particular, the application of metathesis in the synthesis of BILN 2061, the first reported hepatitis C virus (HCV) NS3 protease inhibitor to have shown an antiviral effect in infected humans, will be presented [4].

References

1. Clavier, H.; Grela, K.; Kirschning, A.; Mauduit, M.; Nolan, S. P., "Sustainable Concepts in Olefin Metathesis" Angew. Chem. Int. Ed. 2007, 46, 6786.
2. Thayer, A., "Making metathesis work. Commercially available metathesis catalysts may help a powerful synthesis tool move into drug manufacturing" Chemical & Engineering News 2007, 85 (07), 37.
3. Michrowska, A.; Grela, K., "In a Quest for the Ideal Olefin Metathesis Catalyst" Pure Appl. Chem. 2008, 80, 31.
4. Farina, V.; Shu, C.; Zeng, X.; Wei, X.; Han, Z.; Yee, N. K.; Senanayake, C. H., Org. Proc. Res. Devel. 2009, 13, 250.

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