Synthesis and biological evaluation of new inhibitors of thioredoxin - thioredoxin reductase.
|Szymon Kłossowski 1, Izabela Ziuzia 1, Angelika Szokalska 2, Marta Swiech 2, Jakub Golab 2, Ryszard Ostaszewski 1|
1. Institute of Organic chemistry of the Polish Academy of Sciences (ICHOPAS), Kasprzaka 44/52, Warsaw 01-224, Poland
Thioredoxin system (TR) is responsible for regulating redox state in cell. The system is based on two enzymes: thioredoxin and thioredoxin reductase. Thioredoxin helps tumor to manage oxidative stress, the side effect of very quick proliferation.1 Inhibition of the thioredoxin system will damage this defense system what may sensitize cells to other chemotherapeutics. Some TR inhibitor, such as PX-12, are currently clinically tested in solid tumor therapies.2
Presentation: Poster at VII Multidyscyplinarna Konferencja Nauki o Leku, by Szymon Kłossowski
See On-line Journal of VII Multidyscyplinarna Konferencja Nauki o Leku
Submitted: 2010-03-15 10:13 Revised: 2010-03-15 10:13