Identification of pure pharmaceutical substance (ibuprofen) and its modification masking substances with the use of electronic tongue

Martyna Jańczyk 1Anna Kutyła-Olesiuk 2Krzysztof Sołłohub Krzysztof Cal Patrycja Ciosek 2

1. Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, Warszawa 00-664, Poland
2. Warsaw University of Technology, Faculty of Chemistry, Noakowskiego, Warsaw 00-664, Poland

Abstract

Electronic tongue is an array of sensors (usually electrochemical sensors), used for analysis of complex liquid simples [1]. The analysis of the signals can be performed by PCA (Principal Components Analysis) and other numerical methods. This kind of device allows to recognize the components and taste additives in pharmaceutical products [2].

Ibuprofen is used in medical syrup for children however, it exhibits bitter taste. In order to mask it Hypromellose and Eudragite can be used to modify its flavour.

In this work we present the preliminary studies on the recognition of ibuprofen and ibuprofen modified with taste masking substances with the use of electronic tongue. Potentiometric ion-selective electrodes with PVC membranes (Na+-, K+-, NH4+-, Ca2+-, amine ions-, CO32-, cation-, and anion-selective) were applied in stationary measurements of the samples.

The obtained sensor signals were processed by Principal Components Analysis (PCA) and are presented in Figure 1. It was found, that the presented electronic tongue was capable of the discrimination of pure ibuprofen and ibuprofen modified with two taste-masking substances.

Figure 1. PCA plot of ibuprofen and ibuprofen modified with taste additives (Hypromellose and Eudragite).

[1] Ciosek P., Wróblewski W., Analyst 132 (2007) 963-978

[2] Lorenz J. K., Reo J. P., Hendl O., Worthington J. H., Petrossian V. D., International Journal of Pharmaceutics 367 (2009) 65-72

Acknowledgment

This work has been supported by the European Union in the framework of
European Social Fund through the Warsaw University of Technology Development
Programme and by Project MNS-DIAG Nr POIG.01.03.01-00-014/08-00

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Presentation: Poster at SMCBS'2009 International Workshop, by Martyna Jańczyk
See On-line Journal of SMCBS'2009 International Workshop

Submitted: 2009-08-17 15:10
Revised:   2009-08-23 13:04
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