Identification of pure pharmaceutical substance (ibuprofen) and its modification masking substances with the use of electronic tongue

Martyna Jańczyk 1Anna Kutyła-Olesiuk 2Krzysztof Sołłohub Krzysztof Cal Patrycja Ciosek 2

1. Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, Warszawa 00-664, Poland
2. Warsaw University of Technology, Faculty of Chemistry, Noakowskiego, Warsaw 00-664, Poland


Electronic tongue is an array of sensors (usually electrochemical sensors), used for analysis of complex liquid simples [1]. The analysis of the signals can be performed by PCA (Principal Components Analysis) and other numerical methods. This kind of device allows to recognize the components and taste additives in pharmaceutical products [2].

Ibuprofen is used in medical syrup for children however, it exhibits bitter taste. In order to mask it Hypromellose and Eudragite can be used to modify its flavour.

In this work we present the preliminary studies on the recognition of ibuprofen and ibuprofen modified with taste masking substances with the use of electronic tongue. Potentiometric ion-selective electrodes with PVC membranes (Na+-, K+-, NH4+-, Ca2+-, amine ions-, CO32-, cation-, and anion-selective) were applied in stationary measurements of the samples.

The obtained sensor signals were processed by Principal Components Analysis (PCA) and are presented in Figure 1. It was found, that the presented electronic tongue was capable of the discrimination of pure ibuprofen and ibuprofen modified with two taste-masking substances.

Figure 1. PCA plot of ibuprofen and ibuprofen modified with taste additives (Hypromellose and Eudragite).

[1] Ciosek P., Wróblewski W., Analyst 132 (2007) 963-978

[2] Lorenz J. K., Reo J. P., Hendl O., Worthington J. H., Petrossian V. D., International Journal of Pharmaceutics 367 (2009) 65-72


This work has been supported by the European Union in the framework of
European Social Fund through the Warsaw University of Technology Development
Programme and by Project MNS-DIAG Nr POIG.01.03.01-00-014/08-00

Legal notice
  • Legal notice:

    Copyright (c) Pielaszek Research, all rights reserved.
    The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
    In every case, proper references including Author(s) name(s) and URL of this webpage: must be provided.


Related papers
  1. Planar microsensors based on phenylboronic acid Self-Assembled Monolayers
  2. Hybrid electronic tongue for the quality analysis of apple extracts
  3. The investigation of masking effect of Eudragite with ISE array
  4. Anaerobic digestion monitoring  - application of flow-through sensor array

Presentation: Poster at SMCBS'2009 International Workshop, by Martyna Jańczyk
See On-line Journal of SMCBS'2009 International Workshop

Submitted: 2009-08-17 15:10
Revised:   2009-08-23 13:04
© 1998-2022 pielaszek research, all rights reserved Powered by the Conference Engine