Heparin is an anticoagulant which is widely used during blood-dialysis. To now, there is not a commercial device able to "filter" heparin from blood after or during the medical treatment. Heparin can give, on life-long treatements, several health problems. In the literature, as far as we know, the only practically applied method is a plasmapheresis system that uses polylysine cationic polymers [von Segesser L. K. et al., Perfusion, (2000) 15, 453]. Other polymers that have shown heparin binding properties are PAAs (polyamidoamines), which are widely reported in the literature [Ferruti P. et al., Macromolecular Rapid Communications (2002), 23, 332]. PAAs are prepared from bis-acrylamides and primary or secondary amines or diamines; every NH group can react with one acryl group by a 1,4 Michael reaction. We prepared siloxane-modified hybrid PAAs by introducing (EtO)₃Si(CH₂)₃NH₂ (APTES) or (EtO)₂MeSi(CH₂)₃NH₂ (MAPDES) in the polymerization reaction of diacrylpiperazine (DAP) and N-N-dimethyl-1,6-hexanediamine (C6). The batch solution was then sol-gel processed by addition of a catalyst. The "organic" and "inorganic" polymerizations occur in a one-pot reaction using ethanol and water as solvents. At the end of the reaction a gel is obtained which, after drying, is unsoluble and can be used to effectively absorb heparin form blood. Modifying relative ratios of DAP, C6 and APTES or MAPDES, polymers with different properties can be obtained. These hybrid materials shown good activity in binding heparin as determined by UV spectrophotometry and on blood tests. A patent application has been submitted.

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