Mechanical Properties of Human Plasma Derived Haemostatic Sponges Undergoing Radiation

Leonardo Adamo Pajewski 3Raniero DAscoli 2Katarzyna Filipczak 1Caterina Riccucci 3Janusz M. Rosiak 1Roberto Volpe 3

1. Technical University of Lódź, Institute of Applied Radiation Chemistry (TUL-IARC), Wróblewskiego 15, Łódź 93-590, Poland
2. Baxter Manufacturing S.p.A., Rieti, Italy
3. Department of Chemistry, Chemical Engineering and Materials, Monteluco Roio, L'Aquila 67040, Italy

Abstract

A haemostatic material is designed to arrest bleeding from injured blood vessels. In addition to its properties inherent the capacity to stop blood loss it must exhibit some additional characteristics such as sterility, biocompatibility and purposeful mechanical properties to allow handling and placing it on the blood vessels injury. Here one may appoint a great flexibility and capacity to undergo marked deformations in absence of material failure.
Generally proteins and plasma proteins particularly, are very soft structures and common sterilisation processing with heat treatments leads to their destruction. It is known that the ionising radiation interacts with protein structures inducing their degradation and, also, it is known that proteins can be reticulated with aldehydes which are not properly tissue friendly substances. For these reasons we have investigated the mechanical properties of new hemostatic material derived from human plasma in order to quantify the influence of sterilising dose of radiation (25 kGy) and aldehyde addition. The tests were carried out by means of compressive testing machine.
The results of this investigation, followed by biocompatibilty testing, show the opportunity of an aldehyde weak protein reticulation and the possibility to process material with Co60 radiation.

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Presentation: poster at E-MRS Fall Meeting 2004, Symposium B, by Leonardo Adamo Pajewski
See On-line Journal of E-MRS Fall Meeting 2004

Submitted: 2004-04-29 11:24
Revised:   2009-06-08 12:55
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