This talk will describe a process called liquid sintering in which an injectable paste can convert into a mechanically strong and highly porous material at body temperature. Liquid sintering does not involve any chemical crosslinking or solvent removal. There is no exothermic reaction to achieve the hardening. Therefore, the material can act as a deliver system for temperature and/or solvent sensitive molecules and cells. The work presented here descirbed an injectable scaffold for orthopaedic applications that hardens to the compressive strength of cancellous bone in vivo. We demonstrate the delivery of BMP-2, VEGF and mesenchymal stem cells to accelerate bone regeneration.

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