There are two possible applications of DNA as a structural material for construction of nano-scaled devices. Metallization of DNA was invented as a perspective method for the construction of conductive wires for nano-scaled electrical circuits. The DNA can also be used as a scaffold for the clamping of the DNA-binding ligands that possess appropriate electrical, optical and magnetic properties. An obvious advantage of this approach is that DNA is accessible for modification with an aid of different enzymes. Using a systematic computational search, new single-stranded and two-stranded structural motifs isohelical to double-stranded DNA were found. These motifs can be used for design and synthesis of new generations of sequence-specific DNA-binding oligomers. Isohelical oligomers that possess conjugated p electron systems can serve as conductive wires in nano-scaled devices.Template-assistant organic synthesis and photopolymerization can be used to generate very long oligomers. New strategies are developed for  synthesis of sequence specific DNA -binding oligomers which recognize  long DNA sequences. Bis-netropsins  were synthesized which contain two netropsin-like fragments  attached to a pair of peptides Gly-Cys-Gly-Gly-Gly  and Gly-Val-Gly-Cys-Gly-Gly-Gly bridged by S-S bonds. These conjugates  possesses a  composite binding specificity: the peptide dimers recognize sites with  sequences GCCG  and GCCCCG on DNA, whereas the  netropsin fragments bind selectively to runs of four AT-base pairs. A series of new ligands were synthesized by a modular assembly of pyrrole carboxamides and isohelical pseudopeptides  of the form (XY)n . Here Y is a glycine residue; n is the degree of polymerization. X is an unusual amino acid residue containing five - membered aromatic ring (furan, thiazole, oxazole, imidazole). Studies on binding of these compounds to DNA will be reported.

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