Stability of iron-based carbon nanotubes in biological media
|Nataly V. Boshytska , Olena A. Ivashchenko , Emanuil V. Priloutsky , Iryna V. Uvarova|
Institute for Problems of Materials Science, National Academy of Sciences of Ukraine, Krzizanovsky, Kyiv 38(044), Ukraine
The interaction of nanotubes with antibodies, which are used in biomedicine for diagnostic of cancer decease, has been studied. Immune system generates antibodies, as response to the appearance of foreign antigens in organism. Taking into account advantages of carbon nanotubes as antibody carriers it is necessary to investigate their corrosion stability in biological media, such as human blood plasma and digestive juice.
For safe use of nanotubes in medicine, the knowledge of their behaviour in media of living organism is very important. These media are multicomponent complex systems. For example, digestive juice contains albumens, organic and inorganic acids, mucopolysaccharides, ferments, slime, which makes difficulties in preparation of samples for analysis.
Interaction of nanotubes prepared by reduction of carbon monoxide with human blood plasma and physiological solutions (0,9 % NaCl, Ringer, Ringer - Lokk) has been studied. It was shown that carbon nanotubes containing 33 and 50 mass % of iron are stable enough both in human blood plasma and in physiological solutions. The iron concentration in human blood plasma changed slightly after the interaction.
Magnetic characteristics of carbon nanotubes and sorbtion capability towards methylene-blue do not practically change after interaction with human blood plasma.Thus, iron carbon nanotubes with 30-50 mass % iron slightly interact with human blood plasma and can be used as advanced carriers of specific antibodies for identification of cancer center in living organism.
Presentation: Poster at E-MRS Fall Meeting 2008, Symposium H, by Nataly V. Boshytska
See On-line Journal of E-MRS Fall Meeting 2008
Submitted: 2008-05-07 14:55 Revised: 2009-06-07 00:48