The cytotoxic activity of glycosides of indolo[2,3-b]quinoline derivatives.
|Katarzyna Badowska-Rosłonek 1, Agnieszka Ciesielska 1, Marta Świtalska 2, Joanna Wietrzyk 2, Łukasz S. Kaczmarek 1, Wanda Peczyńska-Czoch 3|
1. Pharmaceutical Research Institute (IF), Rydygiera 8, Warszawa 01-793, Poland
The cytotoxic activity in vitro of glycosides of indolo[2,3-b]guinoline ( 5H and 6H series) were tested against cervix carcinoma cell line (KB).
The cells were placed in 96-well flat-bottom plates at a density of 1x104 cells per well in 100 ml of cultured medium 24 hours before addition of the tested compounds. The cells were exposed to the test compounds at concentrations 0.1, 1, 10, and 100 mg/ml for 72 h. The in vitro cytotoxic effect of all agents was examined using the SRB assay.
We found that all tested indoloquinolines showed cytotoxic activity against KB cells and the most potent were two of them: IBR-15 (ID50: 0,29±0,12 mg/ml) and IBR-17 (ID50: 0,33±0,08 mg/ml). The 5H serie was more active against cervix carcinoma cell line than 6H one.
Presentation: Poster at VI Multidyscyplinarna Konferencja Nauki o Leku, by Marta Świtalska
See On-line Journal of VI Multidyscyplinarna Konferencja Nauki o Leku
Submitted: 2008-04-07 10:58 Revised: 2009-06-07 00:48