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Nanomaterials for Biomedical Applications

Thomas Tsakalakos 

Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ 08854, United States

Abstract

While general principles of nanotechnology are clear, systematic and comprehensive studies of the effects of processing and the resultant evolution of structure on the overall functional properties, performance and thermal stability, under complex loading conditions, have thus far not been performed in sufficient depth. This overview will emphasize the “on development” of useful implementations and applications of nanotechnology. One way to address this question is by using bio-inspiration – techniques, where we apply lessons learned from living systems, to design new materials with localized feedback mechanisms.  This approach leads naturally to the development of multifunctional nanomaterials for use in applications through basic research of bio-inspired nanostructural materials.  Nanoparticles are generating much enthusiasm in molecular biology and medicine due to their unique optical properties, facile surface chemistry, and appropriate size scale. Noble metals, especially Au, nanoparticles have great potential for cancer diagnosis and therapy due to their surface plasmon resonance enhanced light scattering and absorption. Magnetic nanoparticles show promise in vivo as site specific drug delivery agents. Iron oxide, magnetite (Fe3O4) specifically, has been the focus of most With this behavior, it is hoped that the particles can literally be dragged with a magnet to wherever is needed. In this preliminary study, the effects of gold sodium thiomalate (Myochrysine) and magnetite (Fe3O4) nanoparticles on human intestinal primary epithelial cell (HIPEC) growth, differentiation, and function is observed and measured. Differentiation is observed via optical microscopy imaging, proliferation is measured via a cell count, and function is measured via IL-8 cytokine analysis. It was found that Myochrysine had inhibitory effects on cell function and that magnetite caused abnormally large cell size in HT-29 cells.

 

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Related papers

Presentation: Invited at E-MRS Fall Meeting 2007, Acta Materialia Gold Medal Workshop, by Thomas Tsakalakos
See On-line Journal of E-MRS Fall Meeting 2007

Submitted: 2007-07-01 15:03
Revised:   2009-06-07 00:44