Present-day methods of organic synthesis are mostly based on chemical modification of substrates, reagents, and catalysts. Nevertheless, frequent use has recently been made of new, nonconventional techniques, such as high-pressure procedure. Some important problems of organic synthesis have been recently solved using the high-pressure technique. Among them, preparation of synthetic macrocyclic molecular receptors is one of the most important examples.
In this presentation, we would like to show the progress in the high-pressure synthesis of macrocyclic compounds, such as diazacoronands, bi- and tricyclic cryptands in both achiral and nonracemic chiral forms. Some examples of such molecular receptors will be also shown.